PRINT ISSN 1222-5304, ISSN-L: 2065-1295, ISSN CD: 2343-9394,ISSN ONLINE 2067-3663
 

COMPARATIVE STUDY OF OSTEOMYELITIS REPRODUCED ON RABBITS USING HUMAN STRAINS OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND METHICILLIN-RESISTANT STAPHYLOCOCCUS EPIDERMIDIS (MRSE)

Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVI, Issue 2
Written by Diana-Larisa ANCUŢA, Teodoru SOARE, Diana SOARE, Maria CRIVINEANU, Cristin COMAN

One of the current concerns regarding orthopedic surgery is represented by the associated infections. Studies show that in 80% of human cases, the primary bacterial agent that causes osteomyelitis is Staphylococcus aureus. On the other hand, the epidemiological data claims that coagulase-negative staphylococcus, especially Staphylococcus epidermidis, have emerged as the predominant pathogens of the associated infection due to their ability to develop biofilm. The goal of the study was to induce osteomyelitis in rabbits using bacterial strains isolated from human patients and to optimize the concentration of the two species of staphylococcus capable of reproducing bone infection. The evaluation of the disease installation and the clinical evolution was completed by hematological and histological examinations. Comparing the results, it can be concluded that the MRSA strain is more pathogenic compared to MRSE. In both cases, the rabbit has been shown to be a good experimental model for the reproduction of osteomyelitis that can be used for the development of new treatments.

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