CLINICAL AND MORPHOPATHOLOGICAL ASPECTS IN ANTI-FREEZE INTOXICATION OF DOGS

Published in Scientific Works. C Series. Veterinary Medicine, Vol. LVIII ISSUE 4
Written by S.A. Pașca, Gh. Solcan, E.V. Șindilar, M. Lazăr

Anti-freeze intoxication is most frequently encountered in dogs and cats after accidental consumption of the liquid emptied from car radiators. In ruminants, the intoxication can appear as a consequence of erratic contamination of grazing fields with the liquid from tractor tires. Other cases have been reported, due to erronate treatments applied to silage, when ethilenglicole is mistaken taken for formic acid, or after contaminated water consumption. Ethylen glycol is oxidized by alcohol dehydrogenase in the liver to glycoaldehide, wich is in turn oxidized to glycolic acid, glyoxalate, and finally, oxalate. Calcium oxalates crystals may be found in tubular lamina, tubular cells and the interstitium; they are light yellow, arranged in rosettes or prisms, and are birefringent in polarized light. Tubular lesions range from fat degeneration to necrosis. Large numbers of crystals in tubules are pathognomonic for ethylene glycol poisoning.

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Pașca S.A., Solcan Gh., Șindilar E.V., Lazăr M. 2012, CLINICAL AND MORPHOPATHOLOGICAL ASPECTS IN ANTI-FREEZE INTOXICATION OF DOGS. Scientific Works. C Series. Veterinary Medicine, Vol. LVIII ISSUE 4, PRINT ISSN 1222-5304, 296-305.


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