ATTENUATION OF OXIDATIVE STRESS BY ETHANOLIC EXTRACT OF NETTLE (URTICA DIOICA) IN MICE

Published in Scientific Works. C Series. Veterinary Medicine, Vol. LVIII ISSUE 3
Written by Corina Predescu, Camelia Papuc, Maria Crivineanu, V. Nicorescu

This study was undertaken to evaluate the antioxidative potential of ethylic fraction of nettle (Urtica dioica) in stressed mice. In this present study mice were divided into the four groups and each group containing five mice. Group I mice were orally administered with 1 ml of 0.9% NaCl with is the positiv control group. Group II mice were administered with ethylic fraction of Urtica dioica. Group III stressed mice were orally administered with 1 ml of 0.9% NaCl with is the negativ control group. Group IV stressed mice were administered with ethylic fraction of Urtica dioica. The activity of enzymic antioxidants (U/ mg of protein) such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were found to be significantly high in ethylic fraction treated stressed mice when compared to the negative control mice. The levels of nonenzymic antioxidant such as reduced glutathione in the ethylic fraction treated stressed mice was found to be significantly higher than that found in control mice. These results suggest that nettle (Urtica dioica) has very good antioxidant and hepatic protective effect of oxidative stress in mice. Currently, the importance of oxidative stress in the pathophysiology of many disorders has been highlighted, thus use of this plant as an herbal medicine is highly recommended.

[Read full article] [Citation]

Predescu C., Papuc C., Crivineanu M., Nicorescu V. 2012, ATTENUATION OF OXIDATIVE STRESS BY ETHANOLIC EXTRACT OF NETTLE (URTICA DIOICA) IN MICE. Scientific Works. C Series. Veterinary Medicine, Vol. LVIII ISSUE 3, PRINT ISSN 1222-5304, 210-217.


The publisher is not responsible for the opinions published in the Volume. They represent the authors’ point of view.
© 2012 Scientific Papers. C Series. Veterinary Medicine. All Rights Reserved. To be cited: Scientific Papers. C Series. Veterinary Medicine
Powered by INTEL TECH DEVELOPMENT.