Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVIII, Issue 1
Written by Ionuț Răzvan DOBRE, Diana Mihaela ALEXANDRU
One of the most affected species by various toxic substances is, undoubtedly, the canides. Among them, ethylene glycol is one of the most possible causes, its use as an antifreeze solution making it a frequently encountered substance. Because of its sweet taste, it is eaten with pleasure by dogs and not only. The aim of the study was to optimize the diagnostic and treatment methods in ethylene glycol poisoning in dogs. In this study were included 8 clinical cases of dogs (2 males and 6 females), aging from 4 months to 13 years, that were isostenuric after 3 hours after ingestion. Also, calcium oxalate crystalluria becomes detectable after 3-6 hours after consumption. After the onset of renal impairment, the value of blood urea nitrogen and creatinine increased, which resulted in glomerular filtration damage. The present study highlights the effectiveness of the treatment in the first 8 hours after ingestion, being very important to slow down the oxidation metabolism of ethylene glycol by alcohol dehydrogenase. The administration of ethyl alcohol or fomepizole (4-methylpyrazole) to dogs presented to the veterinary clinic following exposure to ethylene glycol increase their chances of survival.
[Read full article] [Citation]
