Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVIII, Issue 1
Written by Fabiola IONIȚĂ, Cristin COMAN, Mario CODREANU
The healing of cutaneous wounds is a dynamic process including overlapping phases of inflammation, proliferation, re-epithelialization and remodeling. Proper wound healing is essential for the reestablishment of structural and functional integrity of the damaged tissue. Rodents are valuable biological tools for understanding tissue repair process and for developing effective treatment strategies, despite anatomical and physiological differences between human and animal skin. The purpose of the study is to evaluate the cutaneous wound healing assessment for an excisional wound model in rats, for further testing with innovative medical devices loaded with biological active compounds. CD-SD female rats were surgically operated to excise one full‐thickness circular skin patch, 20 mm diameter, in the dorsal region. Patches applied were changed every other day and samples of wounds/scars were collected on the 7th and 14th postoperative days. Macroscopic monitoring and histopathological examination assessed the wound healing process over time. Results showed that rats provide an optimal animal model for cutaneous wound healing, as data obtained can provide valuable translational information and can contribute in optimizing treatment protocols.
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