Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVIII, Issue 1
Written by Emilia UNGUREANU, Sergiu Dan ZĂBLĂU, Marina SPÎNU, Diana Ioana OLAH, Adrian Valentin POTÂRNICHE, Monica Ioana SUĂTEAN, Florina MARIAN, Gheorghe Florinel BRUDAȘCĂ
In the last century, antimicrobial therapy evolved from being one of the most important achievements in the history of medicine to one of the major global health challenges. The overdosing of antimicrobial substances was held responsible for the appearance and the worsening of the antibiotic resistance phenomenon. Thus, scientists were called to design and implement new strategies surmounting the shortcomings of the antibiotic therapy. Nanotechnology has revealed promising solutions to the overdosing problem by use of tailored antibiotic administration schemes, both as dosage and administration route. The aim of this review is to highlight the role of nanotechnology in preventing and controlling antibiotic resistance, also emphasizing its advantages and limitations, for a better understanding of the current trends. The paper is based on scientific articles and systematic reviews identified on the Web of Science database, centralized and classified according to specific keywords. Due to their unique physico-chemical properties, the nano-based delivery systems described could become an important mean of avoiding irrational employment of antibiotics by usage of the minimal clinically active amount.
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