Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVIII, Issue 1
Written by Paul-Adrian BOR, Gheorghița DUCA, Carmen Dana ȘANDRU, Diana OLAH, Marina SPÎNU, Emoke PALL, Constantin CERBU, Florina MARIAN, Adrian POTÂRNICHE, Aurel VASIU
Anti-anthrax vaccination is stressful for animals, with a potential negative impact on some immune effectors. This research aimed to investigate the extent of those and estimate the effectiveness of vaccination. Twenty-three extensively raised dairy cows and 11 calves were sampled before and two weeks after the anthrax vaccination (R 1190 Stamatin strain). Blood samples were collected, subjected to blood counts and the N/L ratio was calculated as a stress index. The total Ig (24%o zinc sulphate precipitation) and circulating immune complexes (CIC) (4.2% polyethylene glycol precipitation) were quantified from the serum samples. The N/L ratio was of 0.79 ± 0 .59 before and 0.58 ± 0.45 after the vaccination in adult animals, while in calves it increased significantly (0.61 ± 0.25 and 1.11 ± 0.68, respectively). The total Ig concentrations supported a lesser immunization of the calves than in dairy cows (6.95 ± 2.09 versus 12.10 ± 6.68 Vernes degrees, respectively) supporting the more stressful effect of the primary vaccination than of the booster one. Nevertheless, the antibody clearance was enhanced in the younger animals (5.4 ± 0.25 versus 1.0 ± 0.1 ODU, respectively). Repeated stimulation is the substrate for an enhanced adaptive response to vaccination in cattle.
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