Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVII, Issue 1
Written by Diana-Larisa ANCUȚA, Maria CRIVINEANU, Teodoru SOARE, Cristin COMAN
The biological interface between the host tissue and the medical device used may influence clinical outcomes. Expected effects include osteoinduction, osseointegration, increased vascularity, and mechanical stability. The aim of the study was to evaluate the process of bone regeneration and potential local effects as results of insert implants treated with innovative biomaterials in the intercondylar rat femur. Two groups of rats, Wistar, were created to which titanium implants were applied to the femoral bone. In one of the groups, the titanium implant coated with Poly (3- hydroxybutyric acid-3-hydroxyvaleric acid) polymer microspheres enriched with fibroblast growth factor 2, vascular endothelial growth factor and bone morphogenetic protein 4 (VGF2) was inserted and in the other group, the implant was untreated. After 6 weeks of clinical monitoring, rats were euthanized, and the implanted femur was harvested for histological analysis. In this study the data obtained showed that VGF2-treated implants contributed to faster bone regeneration, with favorable local effects, compared to untreated implants in which signs of persistent inflammation were.
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