Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVII, Issue 1
Written by Cristina FERNOAGĂ, Raluca Mihaela TURBATU, Alexandru Gabriel NEAGU, Tudor NICULAE, Constantin VLĂGIOIU
Myasthenia gravis is an immune-mediated disease that affects the neuromuscular junction due to the increased production of antibodies directed against the acetylcholine receptors of skeletal muscles. The consequence is the impairment of action potential transmission from nerve to muscles. Although in human medicine, Myasthenia gravis is a well-known condition with diagnostic protocols and several therapeutic strategies, in veterinary medicine diagnosis and therapy for this condition are still challenging. This study presents the case of a 5-year-old male American Staffordshire Terrier referral to the Clinic of Faculty of Veterinary Medicine in Bucharest for a neurological consultation due to a history of fatigue, limb tremor and reluctance to exercise. After the complete physical and neurological examination, the findings were consistent with Myasthenia gravis, so neostigmine methylsulfate was administered intravenously to confirm the diagnosis. Considering the positive clinical reply that was obtained after 15 minutes, a long-term therapeutic scheme was established and the patient was reassessed periodically.
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