Scientific Works Series C. Veterinary Medicine

PRINT ISSN 1222-5304, ISSN-L: 2065-1295, ISSN CD: 2343-9394,ISSN ONLINE 2067-3663
 

RESEARCH REGARDING THE EFFECT OF SOME SYNTHETIC GLUCOCORTICOID HORMONES ON LEUKOCYTES, IN RATS

Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXV, Issue 1
Written by Gavrilă ZAGRAI, Cristian BELU, Cerasela VASILESCU, Diana LICSANDRU, Aurel DAMIAN, Ana Maria ZAGRAI (MAIEREAN), Livia PĂUN

In this paper, the assessment is to investigate the effect of some synthetic glucocorticoid hormones (used frequently in therapy) on leukocytes (WBC and leukocyte formula), in rats. It is mentioned that the hormones used in this study (Prednisone, Dexamethasone and Betamethasone) have a large utilization in therapy due to the anti-inflammatory effect, overlooking in many cases the immunosuppressive effect. The determinations regarding the number of leukocytes and the leukocyte formula have been made using the IDEEX Analyzer, at the beginning and at the end of the experiment. As a result of the analysis it was revealed that the WBC%, at the end of the experiment, was higher, for all the experimental groups, comparing with the control group. After the interpretation of the obtained results regarding to the values of the leukocyte formula in the case of the experimental groups, it was shown increases of the percentages of neutrophils and basophils, decreases of percentages of eosinophils, lymphocytes and monocytes, comparing to the values obtained for the control group.

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