Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXV, Issue 1
Written by Ionuț Răzvan DOBRE, Diana Mihaela ALEXANDRU, Maria CRIVINEANU
NSAIDs have the ability to suppress the inflammatory process. They have antithrombotic action at low doses, analgesic and antipyretic action at medium doses and anti-inflammatory effects at elevated doses. Whereas the beneficial effects of NSAIDs are often overshadowed by the adverse effects, the aim of the study is to track side effects on hematology parameters after administration of anti-inflammatory NSAIDs in dogs. The study was performed on 8 dogs, male and female, of different races and ages, to whom were administered Flunixin, Metacam and Carprofen. The side effects on haematological parameters were observed and analyzed, when given medication as prescribed. In the case of Flunixine, increased white blood cell counts and decreased number of red blood cells, hematocrit have been observed. Metacam and Carprofen caused a lower decrease in hematocrit and red blood cell counts, as well as increased leucocyte counts. In all cases, a decrease in platelet count and a prolongation of prothrombin time were observed. This study conducted to the conclusion that the substances used didn't cause significant haematological changes, at the same time having a constant antithrombotic action and favouring coagulopathies.
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