Scientific Works Series C. Veterinary Medicine

PRINT ISSN 1222-5304, ISSN-L: 2065-1295, ISSN CD: 2343-9394,ISSN ONLINE 2067-3663
 

PRELIMINARY CLINICAL EVALUATION OF MESENCHYMAL STROMAL CELL TREATMENTS FOR UNUNITED ANCONEAL PROCESS AND LEGG-CALVE’-PERTHES DISEASE IN DOGS

Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXV, Issue 1
Written by Antonello BUFALARI, Alberto CROVACE, Antonio DI MEO, Vasilica-Flory PETRESCU Alexandra PETEOACA, Luisa PASCUCCI, Gabriele SCATTINI, Beatrice DEL SAL, Giulia MORETTI

Mesenchymal stromal cells are a population of adult stem cells with a vast potential for tissue engineering as well as regenerative medicine. Ununited Anconeal Process (UAP) and Legg-Calvé-Perthes (LCP) disease are two common growth pathologies in young dogs. Even if these diseases present different manifestations and etiopathogenesis, the attention of modern research has focused on the “restoration” of the same cells that were not developed correctly in these bone defects. The administration of Bone Marrow Mesenchymal Stromal Cells and Bone Marrow Mononuclear Cells containing MSCs in these two types of pathologies could be considered as an innovative but also conservative therapy, allowing the formation of new bone tissue in a minimally invasive way. In this preliminary study we evaluated the improvement of the clinical and also the radiographic condition in 2 dogs with UAP and in 3 dogs with LCP, treated with a single administration of autologous Bone Marrow Mesenchymal Stromal Cells and Bone Marrow Mononuclear Cells.

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