Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXX, Issue 2
Written by Maria-Mihaela IFROSE, Emilia CIOBOTARU-PÃŽRVU
Intestinal lymphoma is a very common malignancy in cats, classified in low-grade intestinal T-cell lymphoma and high-grade intestinal T-cell lymphoma. Even the exact cause of the intestinal lymphoma remains uncertain, there may be a connection between persistent intestinal inflammation, such as inflammatory bowel disease (IBD), and the development of this tumor. Thus, differentiation between inflammation and low-grade lymphoma is always a challenge. This study included 22 cats with digestive syndrome featured by recurrent vomiting and diarrhea which have been also unresponsive to treatment. Full thickness intestinal biopsies from living animals and tissue samples from dead animals have been considered for routine cytopathological and histopathological diagnosis. Polymerase chain reaction for antigen receptor rearrangement (PARR) for T-cell CD3 region of the TCRy chain was used to differentiate lymphoma from non-lymphoma lesions. Cytological and histological findings have been represented by a residual heterogeneous population consisting of neutrophils, eosinophils and small mature lymphocyte, to which is added a dominant contingent of small- to medium-sized or large lymphocytes. Mesenteric lymph nodes contain characteristic cells which were consistent for incipient malignant lymphoid proliferation. PARR test discriminated 11 cases of T-cell lymphoma showing strong performance for discrimination of lymphoma from IBD.
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