Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXVIII, Issue 1
Written by Florin-Petrișor POSASTIUC, Alexandru Ilie DIACONESCU, Nicolae Tiberiu CONSTANTIN, Cătălin MICȘA, Mario CODREANU
Testicular cancer is a frequently encountered pathological entity, which is distinguished by wide morpho-histological variability. Only recent research efforts were able to highlight, throughout advanced diagnosis techniques, certain biochemical, immunological and hormonal characteristics. In men, testicular cancer is one of the most common malignant oncopathologies, the usually affected age group being 25-35 years. Statistically, the increasing prevalence in humans can be correlated with veterinary in-field reports, an increase in canine testicular cancers being incriminated. Practically, 90% of the tumours with genital localization, in dogs involve the testicular parenchyma, this being the second most common site of neoplastic evolution in intact males. The aim of this paper was to review scientific papers published, regarding potential biomarkers for testicular cancer in dogs such as the anti-Müllerian hormone, insulin-like factor 3, α-fetoprotein, lactate dehydrogenase, c-KIT, CD-30, placental alkaline phosphatase and cytokeratins expression. Furthermore, this paper intends to lay the foundation for further research in order to establish proper screening protocols for testicular cancer similar to those used in human medicine.
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