Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXIV, Issue 2
Written by Alina ȘTEFĂNESCU, Bogdan Alexandru VIȚĂLARU
Central venous catheter associated infections are the major cause of morbidity and mortality in patients undergoing hemodialysis. Lockings with antibiotics associated with heparin are used for both prophylaxis of infections and central venous catheter longevity. The present study was conducted on 20 dogs treated in the Hemodialysis Clinic from the Faculty of Veterinary Medicine Bucharest. 10 dogs received a locking with 2500 IU/ml heparin combined with vancomycin 2.5 mg/ml and 10 had locking with 5000 IU/ml heparin. Locking solutions were maintained for 24 hours in each patient. Local reactions were observed on the jugular vein, and the central venous catheter function was evaluated in each patient. Catheters were maintained at least 10 days. There were no local reactions in the batch with vancomycin and heparin locking. In the heparin locking batch, local reactions occurred in three subjects on the third day, and central venous catheter functioning progressively altered until day 10. Locking with heparin and vancomycin are an effective alternative, the catheter having a longer maintenance period. Combining an antibiotic with heparin provides superior results to prevent catheter-related infections.
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