Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXIV, Issue 1
Written by Ana Maria GOANȚĂ, Roxana IGNĂTESCU (ȚÎMPĂU), Ana Maria Alexandra STĂNESCU, Valentina Alina SIMION, Lucian IONIȚĂ
Electrophoresis defines the migration of charged particles in an electrical field in accordance to their molecular charge and size. In clinical medicine, electrophoresis is used mainly to separate and thus differentiate between and proteins in a given sample, be it serum, urine, cerebrospinal fluid or others. This paper aims to briefly describe the fundamentals and scope of electrophoresis and review the most recent knowledge on urine protein electrophoresis. Urine electrophoresis (UEP) is always evaluated in conjunction with serum electrophoresis and a measurement of total urine protein. In human medicine, proteinuria has been identified and characterised based on this criterion. UEP can also be used to differentiate between glomerular and tubular disease, based on the quantity and size of the molecules. Considering the advances in human medicine and the wealth of disorders that can present with proteinuria in animals, the authors consider that this diagnostic technique deserves more attention in veterinary medicine, in particular as a valuable aid in the detection and identification of renal lesions.
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