Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXIV, Issue 1
Written by Nicolae Tiberiu CONSTANTIN, Alexandru ȘONEA
After the voluntary waiting period, a chronic uterine infection or a persistent inflammation in the cow may be associated with disruption of the architecture of the endometrial layer and glandular hypersecretion. The aim of our work, the first of this kind in Romania, was to evaluate the efficacy of 3% N-acetylcysteine (NAC) against the clinical endometritis. The mucolytic effect of NAC can be use to break up mucus produced by an glandular irritated layer. Besides this, NAC has a antioxidant, cytoprotection and antiinflamatory role, and at a 8% concentration it can be bactericidal. This study was carried out between 2016-2017 on 43 cows with clinical signs of endometritis after 50-60 days postpartum from a dairy farm situated in Ploiești county. The clinical endometritis was diagnosed by evalution of uterine discharge detected in the vulva. Cows were randomly splited to NAC treatment (NAC) and non-NAC treatment (nNAC) groups. All of these were clinically evaluated, and a cervical swab for microbiology laboratory was collected. The NAC group (n=21) received an intrauterine treatment of enrofloxacin+oxitetraciclin+iodoform (2.5g+5g+5g/100ml) in 20 ml dosages. After 12 hours, an infusion of 3% NAC was intrauterine administred for 3 days. The nNAC group received 20 ml of saline, for 3 days instead of 3% NAC and the same quantity of enrofloxacin+oxitetraciclin+iodoform solution. The clinical heal rate was definited as the percentage of females with no signs of clinical endometritis (clear mucus at the vaginoscopy), at the examination in first estrus following treatment. Cows were artificially inseminated following the hormonal therapy. As a main conclusion, the group of cows treated with NAC presented a pregnancy rate of 66.7% in contrast with non NAC group, where the pregnancy rate was 54.6%.
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