Scientific Works Series C. Veterinary Medicine

PRINT ISSN 1222-5304, ISSN-L: 2065-1295, ISSN CD: 2343-9394,ISSN ONLINE 2067-3663
 

POLI-CHEMOTHARAPY, HORMONAL THERAPY AND IMMUNOTHERAPY IN CANINE PATIENTS (DOGS) WITH PROSTATE CANCER

Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXI
Written by Raluca NEGREANU, Florin GROSU, Dan CRÎNGANU

Incidence of malignant tumors in dogs has increased in recent years due to the abundance and the high level of aggressiveness of oncogenic environmental factors, food and contraceptives. Prostate tumors in male dog rank 3rd in frequency after malignant lymphoma and bone tumors. Determining-factor analysis revealed that prostate malignancies in dogs as in humans correlate with age, diet and sexual activity - uncastrated and hormonal contraceptive therapies based on synthetic hormone substitutes. Maximum frequency of occurrence for this type of disease is between 10-12 years, the majority of male dogs older than 15 years suffering from it. Poli-chemotherapy, immunotherapy and hormonal therapy for the hormone dependent tumors is based on the existence of receptors for sex hormones on the cell membranes that form the prostate's secreting tissue. Administration of variated medication at the same therapeutic moment allows prolonged remission, subtitutes surgical excision of the prostate gland tumor, a very delicate procedure and prevents acquired chimio resistance. Non-specific immunotherapy works by restoring suppressed immune functions to the patient affected by the neoplastic disease.

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