Published in Scientific Works. Series C. Veterinary Medicine, Vol. 19 ISSUE 3
Written by Dumitru MILITARU, Virgilia POPA, Daniela BOTUS, Beatrice STIRBU
Artemisinin, an extract of sesquiterpene lactone endoperoxide obtained from Artemisia annua, is routinely used in the treatment of malaria and various forms of human cancer. In order to extend its therapeutic range on animals and to set up models for testing similar extracts from other plants, studies were done on Artemisinin cytotoxicity on chicken embryo fibroblasts (CEF) in parallel with tests on Vero cells and the effect assessment on Salmonella spp strains of avian origin (4 Salmonella enteritidis, 2 S. typhimurium, 1 S. gallinarum). The cytotoxic effect was recorded for Artemisinin amounts higher than 177.10 nM on CEF and for 4.42 nM on Vero cells. In disk diffusion antibiogram the two concentrations had no antibacterial effect (inhibition diameters were of 6-9 mm)
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