Published in Scientific Works. Series C. Veterinary Medicine, Vol. 19 ISSUE 4
Written by Cristina-Elena DINU-PÎRVU, Mihaela Violeta GHICA, Alina ORTAN, Alexandru Nicolae POPESCU, Letitia PURDOIU, Lacramioara POPA
The aim of this study was the design of some topical drug systems such as hydrogels incorporating ibuprofen as a nonsteroidal antiinflammatory drug, having improved drug release characteristics and adequate rheological profiles, allowing a suitable spreading at the cutaneous administration of these formulations. The ibuprofen release profiles were obtained and analysed for the designed hydrogels, compared with the commercial Ibuprofen 5% (w/w) from Urgo. The kinetic experiments recommended the hydrogel containing the same weight of drug (ibuprofen 5% w/w) with the ingredients hydroxyethyl cellulose and glycerol, with a superior value for the diffusion coefficient and drug percentage released. The rheological studies confirmed the influence of formulation characteristics upon the primary biopharmaceutical profiles for the tested ibuprofen hydrogels.
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