Published in Scientific Works. C Series. Veterinary Medicine, Vol. LVIII ISSUE 4
Written by B. Al. Viţălaru, D. Crânganu, G. Polter
In Romania, monochemotherapy using exclusively Vinca Rosea alkaloids created mutant cellular clones of Sticker sarcoma, activating MDR severe mutant genes. Materials and Methods: During this study, a number of 10 dogs with TVT, of different breeds, genders and ages have been studied. Blood tests, X-Rays, coagulation profile, biochemistry of the blood, urine dipstick, abdominal ultrasound and cytology - FNA from the biopsy mass were performed. All the submitted samples were analyzed in reference laboratories from both Romania and Netherlands. The history, clinical and histological findings were all compatible with TVT. The approach was different in the two Clinics. In UK, the therapeutic approach was different, using Vincristine 0,7mg/m2 week one, repeated every 7 days three more times. In Romania, monochemotherapy created mutant cellular clones of Sticker sarcoma. Therefore, polychemotherapy has been used (genital localization, expansive and proliferate pattern with no metastases). Preoperative, neoadjuvant polychemotherapy for cytoreduction, based on ciclophosphamide 50mg/m2 or ifosfamide 200mg/m2, cyclo dependent cytostatics, and 5-fluorouracil as an antimetabolite, 50mg/m2 and Vincristine 0,7mg/m2 week one, repeated every 14 days or after surgery to prevent recurrence. Results: All cases treated in UK with Vincristine and all Romanian dogs treated with polychemotherapy shown remission of the penile masses and complete healing. In Romania, monochemotherapy created mutant cellular clones. Conclusion: Numerous cases of TVT in the free dog population in Romania and uncontrolled breeding, along with the absence of neutering (castration) favored the spread of tumors and the transmission of resistance from one dog to another.
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