Published in Scientific Works. C Series. Veterinary Medicine, Vol. LVIII ISSUE 4
Written by tutunaru alexandru cosmin , leau florin, şonea alexandru, sandersen charlotte
Alfaxalone is a neurosteroid with general anesthetic properties. His steroid structure, analog with progesterone, might have an influence on patient glycaemia. The aim of our study was to assess variations of glycaemia after alfaxalone induction. For this study we used 7 female adult laboratory rabbits premedicated with fentanyl (0.0125 mg/kg) and droperidol (0.625 mg/kg) intramuscular. Alfaxan® was administered intravenously at a total dose of 3mg/kg by a constant rate infusion over 60 seconds using a syringe pump. Blood samples were drawn prior to and at 2, 4, 6, 10, 15, 20, 30 after induction by an indwelling catheter in the central auricular artery for instant blood glucose determination.Mean value of arterial blood glucose recorded was 154,36 mg/dl (81-262) with the highest peak at minute 4 after induction. Glucose variation remained within normal limits with the highest value at minute 4. Other studies showed an increased in plasmatic glucose after progesterone administration. Women using the progesterone-T intrauterine device showed blood glucose increased after three hours. A study made on rats showed an increase of blood glucose 30 minutes after progesterone administration. The theory that alfaxalone may influence plasmatic glucose have to be further studied on a higher number of animals, however is interesting the fact that in minute four after induction when rabbits suffered the most profound cardio-respiratory depression, blood glucose was at the peak. More extensive monitoring and a pharmacokinetic study are needed to comment accurately on alfaxalone effects on rabbits.
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alfaxalone
