Published in Scientific Works. C Series. Veterinary Medicine, Vol. LVIII ISSUE 3
Written by Cristina Dinu-Pîrvu, Mariana Ferdeş, Alina Orţan, Maria Ichim, Viorica Chiurciu, Alexandru Nicolae Popescu, Letiţia Purdoiu, Simona Ivana
In recent years, a considerable effort was dedicated to researching methylxantine derivatives (MX), because of their effect on the hemorheology, increasing deformability, decreasing the aggregation trend of the red blood cells and the fibrinogen concentration. All of these properties turned MX into a drug eligible to be in peripheral and cerebral vascular disorders. At the same time, the pharmacological profile of MX and their short half-life make it a good candidate for encapsulation of drugs. Lipid nanostructures are a new technology for the encapsulation and delivery of bioactive agents. Because of their biocompatibility and biodegradability, along with their nanosizes, they have potential applications in a vast range of fields. They are able to improve the solubility, bioavailability and stability of bioactive agents, to provide protection of drugs and as well to prevent their unwanted interactions with other molecules, to ensure cellspecific targeting, to minimize adverse effects on healthy cells and tissues. This study aimed at developing the encapsulation of MX into biodegradable, biocompatible and non-toxic carriers. Lipid vesicles were prepared through a physical dispersion method using different ratios of lipids. We studied the changes that occurred in the entrapment efficiency, the particle size and the drug stability when different formulation parameters were modified. The physicochemical properties of the vesicles were significantly affected by the formulation parameters.
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liposomes
