Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXIV, Issue 1
Written by Georgi MARINOV, Nadya ZLATEVA-PANAYOTOVA, Krassimira GENOVA
The use of anesthetics is an integral part of any surgery. Despite their widespread use, their mechanisms and interactions with the nervous-endocrine and immune systems are insufficiently studied.The study was conducted with healthy, adult cats subjected to anesthesia and surgery (ovariohysterectomy) in order to trace the effect of anesthesia and surgery on the secretion of proinflammatory cytokines IL1, IL6 and TNFα. The ovariohysterectomy was performed when a deep plan of anesthesia occurred. Blood samples were obtained at 0 min (prior to anesthetic administration), 30, 60, 120 min and 24 h.The chosen anesthetic schemes modulate the immune response and the response depends on the type of anesthetics used.
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