THERAPEUTIC EFFICACY AND SAFETY EVALUATION OF ERYTHROCYTE CONCENTRATE USED IN DOGS
Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXII, Issue 2
Written by Ildikó BARABÁSI, Viorica CHIURCIU, Constantin CHIURCIU, Laurenţiu OGNEAN
We studied the clinical and hematological changes of 18 dogs from admission day (T0) until 5 days post-transfusion (5 days after the last administered transfusion), as well as hematocrit changes 6 hours post-transfusion therapy with erythrocyte concentrate. This research took place in a period of 6 months in 2014 in a small animal clinic from Germany. Most of the patients have been diagnosed with immune-mediated hemolytic anemia (n=11), 2 with rodenticide poisoning, 1 with babesiosis, 1 with hemangiosarcoma, 1 with septic peritonitis, 1 with idiopathic hepathopathy and 1 with hypothyroidism. The 18 patients received a total of 30 transfusions with erythrocyte concentrate in a mean dose of 11.46 ml/kg. Of the 30 transfusions, 6 reached the calculated hematocrit rise 6 hours post-transfusion, 2 had a higher than expected value and 22 did not reach the expected value. The hematocrit value 6 hours post-transfusion was statistically extremely significant (p<0.0001). We have observed positive changes in all hematological parameters 5 days after the transfusion therapy of which 3 have been statistically significant. The red blood cell count underwent a statistically very significant (p=0.0052) change, as has the hemoglobin level (p=0.0085). The hematocrit level had a statistically extremely significant change (p=0.0002) from the admission day until day 5 post-transfusion.