THERAPEUTIC EFFICACY AND SAFETY EVALUATION OF ERYTHROCYTE CONCENTRATE USED IN DOGS

Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXII, Issue 2
Written by Ildikó BARABÁSI, Viorica CHIURCIU, Constantin CHIURCIU, Laurenţiu OGNEAN

We studied the clinical and hematological changes of 18 dogs from admission day (T0) until 5 days post-transfusion (5 days after the last administered transfusion), as well as hematocrit changes 6 hours post-transfusion therapy with erythrocyte concentrate. This research took place in a period of 6 months in 2014 in a small animal clinic from Germany. Most of the patients have been diagnosed with immune-mediated hemolytic anemia (n=11), 2 with rodenticide poisoning, 1 with babesiosis, 1 with hemangiosarcoma, 1 with septic peritonitis, 1 with idiopathic hepathopathy and 1 with hypothyroidism. The 18 patients received a total of 30 transfusions with erythrocyte concentrate in a mean dose of 11.46 ml/kg. Of the 30 transfusions, 6 reached the calculated hematocrit rise 6 hours post-transfusion, 2 had a higher than expected value and 22 did not reach the expected value. The hematocrit value 6 hours post-transfusion was statistically extremely significant (p<0.0001). We have observed positive changes in all hematological parameters 5 days after the transfusion therapy of which 3 have been statistically significant. The red blood cell count underwent a statistically very significant (p=0.0052) change, as has the hemoglobin level (p=0.0085). The hematocrit level had a statistically extremely significant change (p=0.0002) from the admission day until day 5 post-transfusion.

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BARABÁSI I., CHIURCIU V., CHIURCIU C., OGNEAN L. 2016, THERAPEUTIC EFFICACY AND SAFETY EVALUATION OF ERYTHROCYTE CONCENTRATE USED IN DOGS. Scientific Works. Series C. Veterinary Medicine, Vol. LXII, Issue 2, ISSN 2065-1295, 11-16.


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