IN OVO TESTS FOR CARCINOGENICITY, MUTAGENICITY AND EMBRYOTOXICITY

Published in Scientific Works. Series C. Veterinary Medicine, Vol. LX (1)
Written by Branimir NIKOLOV, Any GEORGIEVA, Vasil MANOV, Anton KRIL

The significance of avian models for studying pathological processes including carcinogenesis, both from a chemical and from a biological viewpoint, has been already clearly demonstrated. The in ovo models appear to be the missing link between the in vitro and the in vivo experiments. This approach has considerable advantages: the tests are rapid, less expensive than animal experiments, less hazardous to the personnel, performing the experiments and they have reliable endpoints. Examples include preneoplastic liver lesions in embryonic avian livers in the In Ovo Carcinogenisity Assay (IOCA) and the induction of micronuclei in embryonic avian erythrocytes in hen’s egg test for micronucleus induction (HET-MN). In addition, the use of avian embryos in embryotoxicity testing is discussed.

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Nikolov B., Georgieva A., Manov V., Kril A. 2014, IN OVO TESTS FOR CARCINOGENICITY, MUTAGENICITY AND EMBRYOTOXICITY. Scientific Works. Series C. Veterinary Medicine, Vol. LX (1), ISSN 2065-1295, 72-80.


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