PRINT ISSN 1222-5304, ISSN-L: 2065-1295, ISSN CD: 2343-9394,ISSN ONLINE 2067-3663
 

HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS DURING THE EARLY STAGES OF N-NITROSODIETHYLAMINEINDUCED HEPATOCARCINOGENESIS IN TURKEYS

Published in Scientific Works. Series C. Veterinary Medicine, Vol. LXI
Written by Branimir NIKOLOV, Vassil MANOV, Roman PEPOVICH, Tandzhu MEHMEDOV, Kalin HRISTOV, Krasimira GENOVA, Elena NIKOLOVA, Reneta PETROVA, Any GEORGIEVA, Anton KRIL

Some haematological and biochemical parameters in turkeys, hatched from embryonated eggs inoculated with the proven hepatocarcinogen N-nitrosodiethylamine were studied. Histopathology confirmed the presence of clear-cell and basophilic foci of altered hepatocytes and hyperplasia of cholangiocytes. The application of the chemical carcinogen affected both haematological and biochemical parameters. The established conditions such as thrombocytopenia and increased levels of the major liver enzymes were associated with the process of malignancy. In addition, leukogram abnormalities (leukocytosis, lymphocytosis and neutropenia) as well as hypoproteinaemia, hypoalbuminaemia and hypoglycemia were also observed.

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